Maladaptive Responses to Immune Disorders

Maladaptive Responses to Immune Disorders

MaladaptiveResponses to Immune Disorders

MaladaptiveResponses to Immune Disorders

Maladaptiveresponses to disorders refer to compensatory mechanisms, whichaccording to Huether &amp McCance (2012) have ultimate severehealth complications for the patients.

Thepaper will examine the pathophysiology of both the inflammatory boweldisease and psoriasis and its genetics as factor that affects thedisorders. Additionally, the paper will consider the trigger ofcompensatory mechanisms by the disorders.

Asa common dermatitis, psoriasis has internal and external factors thatcause the disorder. The body mass index and smoking are a few factorscausing psoriasis. Considering psoriasis in not life threatening,patients’ use of multiple drugs may result in the disease shiftinginto complex conditions, for example flare-ups. On the other hand,inflammatory bowel disease presents itself in a different form, forexample ulcerative colitis (UC) and Crohn’s disease (CD) (Turner &ampTurner, 2012). Physiological and maladaptive responses of thisdisorder occur as a result of severe stress. Intensive smoking alsoresults in the disorder.

Itis thus evident from the information above that use of multiple drugsworsens psoriasis disorder than normal conditions. It is possiblethat one remark the similarity between the two disorders above ashaving the same maladaptive and physiological response (McPhee etal., 2003). Major difference is that the responses are caused bydifferent factors. However, smoking is the only similarity, whichshows cause of complication in both disorders.

Inflammatorybowel disease is mostly caused by genetic factors. This is evidencedby an increase in Cohn’s disease prevalence in certain individualsand family lineages. Hunter &amp Kastelein (2012) believe thatchronic immune stimulation is caused by genetic factors, whichtriggers some mycobacteria. On the other hand, there is proofaccording to Huether &amp McCance (2012), that psoriasispathogenesis is influenced by genes, and as a result, take part ininducement and development of the disorder. As a result, it affectspathophysiology of the two disorders since the patients’ relativesare placed at higher risk of being infected because they share thesame genetic composition (Miller, 2013). In conclusion, two differentimmune conditions react to a number of factors different. It istherefore important that health care practitioners are able tounderstand the immune disorders and its pathophysiology factors.


Huether,S. E., &amp McCance, K. L. (2012). Understandingpathophysiology(Laureate custom Ed.) St. Louis MO: Mosby

Hunter,A., &amp Kastelein, R. (2012). Balancing protective and pathologicalimmunity. ImmunityJournal,37 (6), 960-969.

McPhee,S. J., Lingappa, V. R., &amp Ganong, W. F. (2003). Pathophysiologyof disease: An introduction to clinical medicine.New York: Lange Medical Books/McGraw-Hill.

Miller,A. B. (2013). Epidemiologicstudies in cancer prevention and screening.(5th ed., pp. 135-164) New York, NY: Springer.

Turner,S., &amp Turner, R. (2012). Understandingthe epithelial barrier in inflammatory bowel disease.In D.C. Baumgart (Ed.). Crohn’s disease and ulcerative colitis (pp.75-84) New York Springer