Discussion 2 – Week 2 Patho; Arthritis

Discussion 2 – Week 2 Patho; Arthritis


Discussion2 – Week 2 Patho Arthritis


Pathophysiologyof osteoarthritis and rheumatoid arthritis


Rheumatoidarthritis is an autoimmune disorder that affects individuals’joints. The condition leads to the development of warm swollen andpainful joints and pain in the joints worsens after one takes restand normally affects hand wrists and other body joints (Huether andMcCance, 2012). Causes of rheumatoid arthritis are not clear but itis suspected to be a combination of genetic and environmental factorsinfluencing the immune system to attack the joints. Smoking isregarded as an environmental factor to RA. The activation ofautoimmunity leads to the creation of a persistent cellularactivation of immune in joints and other organs consequently leadingto permanent and chronic condition of RA.

Signsand Symptoms of RA

Majorsigns involve inflammation of joints and stiffness leading tomovement problem. Rheumatoid nodules may appear on the skin. Fibrosisin the lungs may develop as the body tries to respond to rheumatoiddisease. Renal amyloidosis may also occur in kidneys due to chronicinflammation. Other signs and symptoms involve anemia.


Osteoarthritis(OA)is a degenerative type of arthritis that leads to breakdown ofcartilage and bone. Biochemical changes takes place in joints leadingto morphological changes on joint tissues.Osteoarthritis(OA)is characterized by loss in Collagen fibers that leads to decrease inproteoglycan content within the cartilage and consequently decreasein osmotic pull.

Signsand Symptoms

Themain symptom is pain and loss in ability and stiffness in finger andwrist joints. All weight bearing joints are affected such as hips,spine, knees and neck.

Similaritiesand differences of the disorders

Onemajor difference between Osteoarthritis(OA)and Rheumatoid Arthritis is that, Rheumatoid Arthritis is largely agenetic disorder that triggers immune system that affects jointswhile Osteoarthritis(OA)is as a result of cartilage and bone due to the biochemical changesthat takes place in joints. The similarity between the two disordersis that they all affects body joints in the legs, hands, spine andlegs (Huether and McCance, 2012).

Patientfactors Genetics and Age

Geneticfactors are to large extent the contributing influence in somearthritis conditions such as Rheumatoid Arthritis and this makes theminherently difficult to treat or diagnosis at early age. RheumatoidArthritis is a genetic disorder that leads to permanent and chroniccondition in the body (Huether and McCance, 2012). Age is anotherfactor that interferes with the pathological, diagnosis and treatmentof arthritis disorders. Arthritis is more prevalent, spreads fasterand affects old people more than young people. Additionally, asindividuals’ advances in age, arthritis condition becomes hard totreat due to wearing out of cartilages. The damage done by arthritisdisorders becomes hard to treat due to complexities of old age.


HuetherSue, E. and McCance Kathryn L. (2012). UnderstandingPathophysiology.Mosby Publishers.